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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3016

Title: Protein and Albumin to Creatinine ratio and their loss in urine associated with Kidney Diseases
Advisors: Prof. Ravi Nagpaul
Keywords: urinary spot microalbumin: Creatinine ratio (MACR)”, “spot albumin-creatinine ratio (ACR)”, “spot protein-creatinine ratio (PCR)” and/or spot “total Protein: Creatinine ratio (TPCR)” vs.
“24-hours urine sample collection”.
Copyright: Jun-2008
Date Added: 11-May-2012
Publisher: AAU
Abstract: Background: Proteinuria is recognized as an independent risk factor for cardiovascular and renal disease and as a predictor of end organ damage. Appearance of albumin in the urine is one of the first sign of deteriorated kidney function. As the kidney functions decreases, the amount of albumin in the urine increases. So, Albumin: Creatinine ratio and/or Protein: Creatinine ratio on random urine sample provides significant results for quantitating proteinuria against conventional 24-hours sample collection. Objective: - To review and recommend the method(s) for quantitating proteinuria using urinary Albumin: Creatinine ratio and/or Protein: Creatinine ratio on random urine samples vis-a-vis conventional 24-hours urine collection for diagnostic evaluation of Kidney function. Methods: I performed a systematic review of literatures on measurement of Albumin: Creatinine ratio and/or Protein: Creatinine ratio on a random urine compared with the conventional 24- hours urine collection method. Results: Data were extracted from 8 studies which investigating proteinuria in several settings. Patient groups in the studied were primarily those with hypertension, diabetic, preeclampsia or renal disease. Urine Microalbumin: Creatinine ratio, Albumin: Creatinine ratio and Protein: Creatinine ratio vs. 24-hours urine specimen has correlation coefficients (r>0.84, p<0.001) except urinary Microalbumin: Creatinine ratio (r ≈ 0.743) and Sensitivities, specificities for the tests were 83% (ranged 66% to 100%) and 76.5% (ranged 53% to 100%), respectively, whereas positive and negative predictive values were 80.5% (ranged 61% to 100%) and 87.5% (ranged 75% to 100%), respectively. Conclusion: The use of Albumin: Creatinine ratio and/or Protein: Creatinine on a random urine specimen provides significant correlation with conventional method of a 24-hours urine specimen collection. The analysis of the report reviewed has also revealed that, total Protein: Creatinine ratio has better sensitivity as compared to Albumin: Creatinine ratio in quantitating proteinuria.
URI: http://hdl.handle.net/123456789/3016
Appears in:Thesis - Biochemistry

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