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|Title: ||Serum magnesium level and magnesium supplementation on Type 2 Diabetes Mellitus: systematic review|
|Authors: ||Sefealem, Assefa Belay|
|Advisors: ||proffessor Ravi Nagpaul|
|Copyright: ||Jun-2011 |
|Date Added: ||4-May-2012 |
|Abstract: ||Objective: To assess the association between serum magnesium levels and risk of type 2 diabetes
and to evaluate the effect of magnesium supplementation on diabetes status.
Design: Systemic review
Data Sources: By the electronic databases searches journals and retrieved studies published in
English language by systematically searching Medline, JCEM, European journals of Clinical
Nutrition and American Medical Association from 1992 to Feb 2011 and by manually examining
the references of the original articles.
Study Selection: includes prospective cohort studies and random case control trials reporting
relative risks with 95% confidence intervals for the association between magnesium intake and
incidence of type 2 diabetes.
Results: Most of the studies included in this review comprising patients of type 2DM showed
significantly lower serum magnesium levels compared to the controls. Magnesium
supplementation studies also showed resulted in significant improvement in serum levels of Mg,
FGL, HDL-C; serum TG levels were found to decrease significantly while plasma cholesterol
levels were not affected.
Conclusions: Serum magnesium levels were significantly low in type 2 DM compared to the
controls group. A direct relationship between the status of Diabetes and Mg levels was also
noted. A significant improvement in serum Mg levels, FGL and HDL-C concentration was
observed after Mg supplementation. No significant difference in levels of serum cholesterol was
Over all the Magnesium supplementation appeared to have improved the insulin sensitivity and
metabolic control in type 2 diabetes mellitus.|
|Appears in:||Thesis - Biochemistry |
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