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|Title: ||HEPATITIS C VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) COINFECTION AMONG ATTENDANTS OF VOLUNTARY COUNSELING AND TESTING CENTER AND HIV FOLLOW UP CLINICS OF MEKELLE HOSPITAL, MEKELLE, NORTH ETHIOPIA|
|Authors: ||HAFTOM, HADUSH|
|Advisors: ||Dr. Solomon Gebre-Selassie|
Dr. Adane Mihret
follow up cliMekelle
|Copyright: ||Apr-2011 |
|Date Added: ||3-May-2012 |
|Abstract: ||Background: Because of shared routes of transmission, hepatitis C virus (HCV) infection is
common in Human Immunodeficiency virus (HIV)-infected persons. HIV and HCV coinfection is
major global health concern. However, limited data of this coinfection are available in Ethiopia.
Objective: The objective of this study was to determine the magnitude of HIV/HCV coinfection
rate and to assess if sociodemographic characteristics and potential risk factors are associated
with HCV seropositivity in consecutive attendants of voluntary counseling and testing (VCT)
center and HIV follow up clinics of Mekelle hospital.
Methods: A hospital based cross-sectional survey was carried out on VCT center and HIV follow
up attendees from December 2010 to January 2011. An interviewer-administered questionnaire
was used to collect data on demographic information and risk factors associated with HCV
infection. The rapid immuno-chromatographic test was applied for detection of HCV antibodies.
Results: Out of a total of 300 consecutive attendants, 135 were VCT center clients and 165 were
HIV follow up cases. There were more females 181 (60.3%) than males, 119 (39.7%). The
overall anti-HCV prevalence was 6.0% (18/300, 95% CI= 3.6%-9.3%). There were no
significant differences in HCV seroprevalence among the different categories of age and sex (p>
0.05). Of the 174 persons with HIV, 16 (9.2%) cases had antibodies to HCV, where as among
126 HIV negative subjects, 2 (1.58%) were HCV seropositive (p= 0.006, OR= 6.28, 95% CI=
1.42-27.82). Accordingly, there was a significant difference in sero-positivity of HCV between
HIV positive and HIV negative participants. No apparent risk factor that caused HCV infection
was inferred from this study (p>0.05).
Conclusion: This study showed a significant percentage of HCV infection in HIV positive cases.
Hence, with emphasis given to HIV positive cases screening for HCV infection has importance.
Based on the result obtained, recommendations were forwarded to build up nationwide hospital
and community-based surveys of HIV/HCV coinfection so that to decipher the prevalence with
the possible risk factors and to increase public awareness about this dual disease.|
|Appears in:||Thesis - Medical Microbiology|
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