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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2350

Title: HEPATITIS C VIRUS AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) COINFECTION AMONG ATTENDANTS OF VOLUNTARY COUNSELING AND TESTING CENTER AND HIV FOLLOW UP CLINICS OF MEKELLE HOSPITAL, MEKELLE, NORTH ETHIOPIA
Authors: HAFTOM, HADUSH
Advisors: Dr. Solomon Gebre-Selassie
Dr. Adane Mihret
Keywords: HCV
prevalence
follow up cliMekelle
HIV hospital
VCT center
prevalence
VCT center
coinfection
Copyright: Apr-2011
Date Added: 3-May-2012
Publisher: AAU
Abstract: Background: Because of shared routes of transmission, hepatitis C virus (HCV) infection is common in Human Immunodeficiency virus (HIV)-infected persons. HIV and HCV coinfection is major global health concern. However, limited data of this coinfection are available in Ethiopia. Objective: The objective of this study was to determine the magnitude of HIV/HCV coinfection rate and to assess if sociodemographic characteristics and potential risk factors are associated with HCV seropositivity in consecutive attendants of voluntary counseling and testing (VCT) center and HIV follow up clinics of Mekelle hospital. Methods: A hospital based cross-sectional survey was carried out on VCT center and HIV follow up attendees from December 2010 to January 2011. An interviewer-administered questionnaire was used to collect data on demographic information and risk factors associated with HCV infection. The rapid immuno-chromatographic test was applied for detection of HCV antibodies. Results: Out of a total of 300 consecutive attendants, 135 were VCT center clients and 165 were HIV follow up cases. There were more females 181 (60.3%) than males, 119 (39.7%). The overall anti-HCV prevalence was 6.0% (18/300, 95% CI= 3.6%-9.3%). There were no significant differences in HCV seroprevalence among the different categories of age and sex (p> 0.05). Of the 174 persons with HIV, 16 (9.2%) cases had antibodies to HCV, where as among 126 HIV negative subjects, 2 (1.58%) were HCV seropositive (p= 0.006, OR= 6.28, 95% CI= 1.42-27.82). Accordingly, there was a significant difference in sero-positivity of HCV between HIV positive and HIV negative participants. No apparent risk factor that caused HCV infection was inferred from this study (p>0.05). Conclusion: This study showed a significant percentage of HCV infection in HIV positive cases. Hence, with emphasis given to HIV positive cases screening for HCV infection has importance. Based on the result obtained, recommendations were forwarded to build up nationwide hospital and community-based surveys of HIV/HCV coinfection so that to decipher the prevalence with the possible risk factors and to increase public awareness about this dual disease.
URI: http://hdl.handle.net/123456789/2350
Appears in:Thesis - Medical Microbiology

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