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Addis Ababa University Libraries Electronic Thesis and Dissertations: AAU-ETD! >
Faculty of Medicine >
Thesis - Pharmacology >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/2326
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| Title: | IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF THE LEAF EXTRACTS AND FRACTIONS OF OCIMUM SUAVE IN MICE MODEL |
| Authors: | BIRHANETENSAY, MASRESHA |
| Advisors: | Prof. Eyasu Makonnen
Dr. Asfaw Debella |
| Keywords: | Pharmacology |
| Copyright: | Oct-2011 |
| Date Added: | 3-May-2012 |
| Publisher: | AAU |
| Abstract: | Ocimum suave has been used in Ethiopian traditional medicine to relieve pain, fever,
inflammation and possibly other diseases conditions. Although there are some reports on
analgesic, antipyretic, antiulcer, antimicrobial and wound healing effects, no study has been
made regarding its possible anti-inflammatory effect. The objective of the present study was,
therefore, to investigate ethanol and aqueous extracts and fractions (butanol and water residue)
of the aqueous extract of the plant material. The ethanol and aqueous extract were screened for
their anti-inflammatory activities on carrageenan-induced mouse paw edema at three dose
levels 400, 600 and 800mg/Kg. The butanol and water fractions of the aqueous extract were
also investigated for their anti-inflammatory activities on carrageenan, histamine and
serotonin-induced mouse paw edema at three dose levels 50, 100, 200mg/Kg. Normal saline
and aspirin (200mg/Kg) were employed as negative and positive control groups, respectively.
Both ethanol and aqueous extracts significantly decreased carrageenan-induced inflammation
at all doses used. Greater paw edema inhibition was, however, observed by the aqueous extract
than ethanol one at 600 and 800mg/Kg dose levels. Similarly, both butanol and water fractions
also showed significant reduction of inflammation induced by carrageenan, histamine and
serotonin in mice paw. Highest inhibition, however, was exhibited by the aqueous fraction at
100mg/Kg and 200mg/Kg dose levels. From the present findings, it can be concluded that the
extracts and fractions of the plant material have got anti-inflammatory properties. Thus the
results support the traditional use of this plant in inflammatory conditions. Further
investigation, however, should be pursued to identify the exact mechanism (s), isolate the
bioactive principle (s) responsible for the anti-inflammatory action and others. |
| URI: | http://hdl.handle.net/123456789/2326 |
| Appears in: | Thesis - Pharmacology
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