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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2326

Title: IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF THE LEAF EXTRACTS AND FRACTIONS OF OCIMUM SUAVE IN MICE MODEL
Authors: BIRHANETENSAY, MASRESHA
Advisors: Prof. Eyasu Makonnen
Dr. Asfaw Debella
Keywords: Pharmacology
Copyright: Oct-2011
Date Added: 3-May-2012
Publisher: AAU
Abstract: Ocimum suave has been used in Ethiopian traditional medicine to relieve pain, fever, inflammation and possibly other diseases conditions. Although there are some reports on analgesic, antipyretic, antiulcer, antimicrobial and wound healing effects, no study has been made regarding its possible anti-inflammatory effect. The objective of the present study was, therefore, to investigate ethanol and aqueous extracts and fractions (butanol and water residue) of the aqueous extract of the plant material. The ethanol and aqueous extract were screened for their anti-inflammatory activities on carrageenan-induced mouse paw edema at three dose levels 400, 600 and 800mg/Kg. The butanol and water fractions of the aqueous extract were also investigated for their anti-inflammatory activities on carrageenan, histamine and serotonin-induced mouse paw edema at three dose levels 50, 100, 200mg/Kg. Normal saline and aspirin (200mg/Kg) were employed as negative and positive control groups, respectively. Both ethanol and aqueous extracts significantly decreased carrageenan-induced inflammation at all doses used. Greater paw edema inhibition was, however, observed by the aqueous extract than ethanol one at 600 and 800mg/Kg dose levels. Similarly, both butanol and water fractions also showed significant reduction of inflammation induced by carrageenan, histamine and serotonin in mice paw. Highest inhibition, however, was exhibited by the aqueous fraction at 100mg/Kg and 200mg/Kg dose levels. From the present findings, it can be concluded that the extracts and fractions of the plant material have got anti-inflammatory properties. Thus the results support the traditional use of this plant in inflammatory conditions. Further investigation, however, should be pursued to identify the exact mechanism (s), isolate the bioactive principle (s) responsible for the anti-inflammatory action and others.
URI: http://hdl.handle.net/123456789/2326
Appears in:Thesis - Pharmacology

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