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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2032

Title: Bacterial Meningitis: a five year retrospective study among patients who had attended at University of Gondar Teaching Hospital
Authors: Birehanemeskel, Tegene
Advisors: Dr. Solomon Gebreselassie
Keywords: bacterial meningitis
antimicrobial susceptibility and pyogenic meningitis
Copyright: Mar-2011
Date Added: 1-May-2012
Publisher: AAU
Abstract: Background: Bacterial meningitis is one of the most serious infectious diseases. The most frequent causes of meningitis are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. The infection usually associated with a high rate of complications. Data on the recent relative magnitude of the bacterial isolation and their antibiotic susceptibility patterns is insufficient in Ethiopia. Objectives: The aim of the study was to determine etiological agents of bacterial meningitis at University of Gondar Teaching Hospital and assess their antibiotic susceptible pattern during last 5 years Methods: This is a retrospective analysis of three thousand and eighty five cerebrospinal fluid specimens submitted to the bacteriology laboratory of Gondar University Hospital for culture and antibiotic susceptibility patterns in a period between January 2006 and December 2010. The study was done from November 1, to December 31, 2010. Results: For this retrospective study data were obtain from 1589 males and 1496 females making male to female ratio 1.06:1 of suspected cases of meningitis in Gondar University Hospital. The etiological agent had been identified in 120 (3.8%) of the total 3085 CSF samples by culture. Thirty- nine (32.5%) of them were infants below the age of 12 months. Streptococcus pneumoniae was the predominant pathogen accounting for 52 (43.3%) of the cases. Whereas Neisseria meningitidis and Haemophilus influenzae accounted for 27(22.5%), and 12(10%) respectively. Other gram negative bacilli and Staphylococcus aureus were isolated from 21(17.2%), and 11(9.2%) cases respectively. Among gram positive organisms S.pneumoniae showed a high level of drug resistance against co- trimoxazole 44(84.3%), tetracycline 17(32.6%), gentamicin 10(19.2%) chloraphinicol 4(7.6%) and ampicillin 3(5.7%). Among gram negative bacteria, N.meningitidis was found to be resistant to Co- trimoxazole in 25(92.5%), Chloraphinicol 2(7.5%), Gentamicin 4(14.8%) and Ampicillin 4(14.8%). E. coli and salmonella spp. were found to be resistant to most antibiotics except ciprofloxacin. Both S. Pneumoniae (7.6%) and S. aureus (18.1%) were found to be resistant to ciprofloxacin. Multiple drug resistance was observed in 58.3% of the isolates. X Conclusions and recommendation: Streptococcus pneumoniae remains the major aetiological agent of Community Acquired Acute Bacterial Meningitis (CAABM) both in adults and children in the study area. 5.7% of Streptococcus pneumoniae were resistances to penicillin. Further research should focus on preventable aspects CAABM of, especially pneumococcal vaccines, to reduce the disease burden.
URI: http://hdl.handle.net/123456789/2032
Appears in:Thesis - Medical Parasitology

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