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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1950

Advisors: Prof. Dr. Manash Kumar Choudhury
Copyright: 2008
Date Added: 21-Jan-2009
Publisher: Addis Ababa University
Abstract: Synthetic, spectroscopic and biological studies of triphenyltinsalicylate pyridine (TPhTSaPy) complex derived from pyridine having a nitrogen donor system have been undertaken. Silversalicylate, on interaction with triphenyltin chloride (TPhTCl), yielded triphenyltinsalicylate (TPhTSa), which upon further interaction of the intermediate (TPhTSa) with pyridine afforded the TPhTSaPy complex having a Sn N bond. The structures of these compounds were elucidated by elemental analysis and spectroscopic (IR, Mass, 1H and 13C NMR) studies. The growth-inhibiting potential of the final product (TPhTSaPy) and its intermediate (TPhTSa) was compared with that of the commercially available antifungal drug TPhTCl against a series of medically important pathogens including fungal, and Gram-positive and Gram-negative bacterial strains. The results revealed that TPhTSaPy was strongly active against Staphylococcus aureus 29737, S. aureus ML 267, Escherichia coli RP4, Pseudomonas aeruginosa ATCC 25619 and Vibrio cholerae 2 while it failed to exhibit any activity against Sarcina luteus 9341, Bacillus subtilis ATCC 6633 and B. pumilus 8241 at the tested concentrations. TPhTSaPy displayed moderate activity against E. coli K88, E. coli ATCC 10536, E. coli VC Sonawave 3:37 C, E. coli 18/9, E. coli CD/99/1, Shigella dysentery 1, S. dysentery 8, S. soneii 1, S. soneii BCH 397, S. boydii 937 and S. flexneri Type 6, V. cholerae 1037 and V. cholerae 785. The lowest MIC (25 μg/ml) value was observed against S. aureus 29737, S. aureus ML 267, E. coli RP4, P. aeruginosa ATCC 25619 and V. cholerae 2. TPhTCl was active against E. coli and V. cholerae 2. But, S. luteus 9341, B. pumilus 8241 and B. subtilis ATCC 6633 strains were completely resistant to it. On the other strains of bacteria it showed moderate activity. The lowest MIC (25 μg/ml) value was observed against E. coli CD/99/1, E. coli 18/9, E. coli K88 and V. cholerae 2. According to these results, TPhTSaPy was more active than TPhTCl against S. aureus, and P. aeruginosa but less active against E. coli. Thus, TPhTSaPy has shown a broad antibacterial spectrum than TPhTCl. But, the activity of TPhTCl against the fungal strains tested in the present study namely, Candida albicans ATCC 10231, Aspergillus niger ATCC 6275, Penicillium notatum ATCC 11625 and P. funiculosum NCTC 287 was superior to that of TPhTSaPy.
Description: A thesis submitted to the School Of Graduate Studies Of Addis Ababa University in partial fulfillment of the requirement for the Degree of Master of Science in Pharmaceutical Analysis and Quality Assurances.
URI: http://hdl.handle.net/123456789/1950
Appears in:Thesis - Pharmaceutical Analysis & Quality Assurance

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