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|Title: ||SYNTHESIS AND ANTIMICROBIAL TESTING OF TRIPHENYLTINSALICYLATEPYRIDINE|
|Authors: ||WALELIGN, FIKADU|
|Advisors: ||Prof. Dr. Manash Kumar Choudhury|
|Copyright: ||2008 |
|Date Added: ||21-Jan-2009 |
|Publisher: ||Addis Ababa University|
|Abstract: ||Synthetic, spectroscopic and biological studies of triphenyltinsalicylate pyridine
(TPhTSaPy) complex derived from pyridine having a nitrogen donor system have
been undertaken. Silversalicylate, on interaction with triphenyltin chloride (TPhTCl),
yielded triphenyltinsalicylate (TPhTSa), which upon further interaction of the
intermediate (TPhTSa) with pyridine afforded the TPhTSaPy complex having a
Sn N bond. The structures of these compounds were elucidated by elemental
analysis and spectroscopic (IR, Mass, 1H and 13C NMR) studies.
The growth-inhibiting potential of the final product (TPhTSaPy) and its intermediate
(TPhTSa) was compared with that of the commercially available antifungal drug
TPhTCl against a series of medically important pathogens including fungal, and
Gram-positive and Gram-negative bacterial strains.
The results revealed that TPhTSaPy was strongly active against Staphylococcus
aureus 29737, S. aureus ML 267, Escherichia coli RP4, Pseudomonas aeruginosa
ATCC 25619 and Vibrio cholerae 2 while it failed to exhibit any activity against
Sarcina luteus 9341, Bacillus subtilis ATCC 6633 and B. pumilus 8241 at the tested
concentrations. TPhTSaPy displayed moderate activity against E. coli K88, E. coli
ATCC 10536, E. coli VC Sonawave 3:37 C, E. coli 18/9, E. coli CD/99/1, Shigella
dysentery 1, S. dysentery 8, S. soneii 1, S. soneii BCH 397, S. boydii 937 and S.
flexneri Type 6, V. cholerae 1037 and V. cholerae 785. The lowest MIC (25 μg/ml)
value was observed against S. aureus 29737, S. aureus ML 267, E. coli RP4, P.
aeruginosa ATCC 25619 and V. cholerae 2. TPhTCl was active against E. coli and
V. cholerae 2. But, S. luteus 9341, B. pumilus 8241 and B. subtilis ATCC 6633
strains were completely resistant to it. On the other strains of bacteria it showed
moderate activity. The lowest MIC (25 μg/ml) value was observed against E. coli
CD/99/1, E. coli 18/9, E. coli K88 and V. cholerae 2.
According to these results, TPhTSaPy was more active than TPhTCl against S.
aureus, and P. aeruginosa but less active against E. coli. Thus, TPhTSaPy has shown
a broad antibacterial spectrum than TPhTCl. But, the activity of TPhTCl against the
fungal strains tested in the present study namely, Candida albicans ATCC 10231,
Aspergillus niger ATCC 6275, Penicillium notatum ATCC 11625 and P.
funiculosum NCTC 287 was superior to that of TPhTSaPy.|
|Description: ||A thesis submitted to the School Of Graduate Studies Of
Addis Ababa University in partial fulfillment of the
requirement for the Degree of Master of Science in
Pharmaceutical Analysis and Quality Assurances.|
|Appears in:||Thesis - Pharmaceutical Analysis & Quality Assurance|
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