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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1941

Title: CHEMOMETRICS ASSISTED UV- SPECTROPHOTOMETRIC DETERMINATION OF TOPICAL BINARY MIXTURES CONTAINING BENZOIC ACID, SALICYLIC ACID OR RESORCINOL
Authors: Mulualem, Kassa
Advisors: Prof.Dr.Abdel-Maaboud I Mohamed
Keywords: chemometrics
derivative spectrophotometry
CLS
PCR
pharmaceuticals
white field ointment
luna soap
dorin emulsion
Copyright: 2008
Date Added: 20-Jan-2009
Publisher: Addis Ababa University
Abstract: Chemometrics-assisted spectrophotometric methods were developed for simultaneous determinations of binary mixtures of (1). benzoic acid and salicylic acid, and (2). resorcinol and salicylic acid mixture. The commercial forms were marketed in Ethiopia and Egypt, such as whitefield ointment, luna soap, and dorin emulsion. The uv absorption spectra of the studied compounds in the range of 200-400 nm, showed considerable degrees of spectral overlapping (between 87.6% for benzoic acid and salicylic acid mixture, and 96.2% for salicylic acid and resorcinol mixture). The resolution of the mixtures have been successfully accomplished by using four techniques namely,1D (first derivative), 1D ratio, CLS (classical least square) and PCR (principal component regression). Variable results were obtained in the different cases as explained in the core of this thesis. Validation parameters such as calibration range, LOD, LOQ, precision and accuracy parameters (Between F- and t-values respectively) were calculated and a comparison between all the methods and some official methods were done. The results showed that the PCR technique was the most suitable for analysis of such binary mixtures or the commercial formulations, more than the other techniques and agrees well with those results obtained from the official method.
Description: A thesis Submitted to the School of Graduate Studies of Addis Ababa University in partial fulfilment of the requirement for the Degree of Master of Science in Pharmaceutical Analysis and Quality Assurance
URI: http://hdl.handle.net/123456789/1941
Appears in:Thesis - Pharmaceutical Analysis & Quality Assurance

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